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The foundation of any medicinal chemistry program for creating innovative medicines begins with the selection of a disease-specific drug target. Drug targets can be molecular receptors, enzymes or transporters. For example, there are about 800 G-Protein Coupled Receptors (GPCRs) that are known to mediate variety of cell sigannling, growth and physiological processes. See Table 1 for a list of currently utilized targets that are encoded by the human genome.

Scientists at PHARMA Inventor Inc., have hands on experience working with many of these drug targets in multiple medicinal chemistry projects.

Image of a G-Protein Coupled Receptor

        Table 1: Classification of the currently utilized drug targets

Drug Targets
Classes

Sub-Classes
Drug Targets

Most Common
Therapeutic Action

 

 

 

Molecular
Receptors

G Protein-Coupled Receptors(GPCRs)

Antihypertensive, Anti-allergic

Ligand-Gated Ion Channels

Hypnotic & Sedative, anticonvulsant

Receptor, Tyrosine Kinases

Antineoplastic, Vasodialators

Immunoglobulin-Like Receptors

Immunomodulatory, Antineoplastic

Nuclear
Receptors

Antineoplastic,
Harmone Replacement

 

 

 

 

Enzymes

EC 1 Oxidoreductases

Anti-inflammatory, Antineoplastic

EC 2  Transferases

Antineoplastic, bisphosphonate

EC 3 Hydrolases

Antihypertensive, Vasodilators

EC 4 Lyases

Antihypertensive, Diuretic

EC 5 Isomerisases

Antineoplastic, Immunosuppressive

EC 6 Ligases

Antineoplastic, Antifibrinolytic

 

 

Transporter
Proteins

Voltage Gated Ion Channels

Anaesthetic, Anti-arrythmia

Other Ion Channels &
Solute Carriers

Antihypertensive, Diuretic

Active Transporters

Antihypertensive, Anti-ulcer

Auxillary Transport Units

Antihypertensive, Vasodialtaors

 

Other
Targets

Enzyme interacting Proteins

Anti-inflammatory, Glucocorticoid

Structural and Adhesion Proteins

Antineoplastic

Ligands

Antirheumatic