PHARMA INVENTOR INC.

About Us

Creative scientists at Pharma Inventor Inc. have published a large number of innovative patents covering various phases of medicinal chemistry, process development and synthetic organic methodology developments. We also have published several peer reviewed research articles in international journals in the areas of natural product synthesis, organo-metallic chemistry, carbohydrate, organometallic catalysis, asymmetric synthesis, glyco-peptide mimetics and so on. Please review the list of patents and publications as shown below:

Patents & International Journal Articles:

1. Optimization of physico-chemical properties of active pharmaceutical ingredients for the treatment of major depressive disorders and methods thereof. McDonald David, Lever Melody, Sadalapure Kashinath, MSI Methylation Sciences Inc. WO/2014 (application in process).

2. Glycine Transporter-1 Inhibitors, methods of making them and uses thereof. Cioffi Christopher L.; Wolf Mark; Guzzo Peter R.; Liu Shuang; Sadalapure Kashinath; Visweswaran Parthasarathy; Maeng Jun-Ho (Albany Molecular Research Inc.), WO/2011/153359 08-December-2011.

3. Methods of using piperazine compounds in treating sodium Channel-mediated diseases or conditions. Kamboj, Rajender; Fraser, Robert; Sadalapure, Kashinath; Fu, Jian-Min; (Xenon Pharmaceuticals Inc., Canada). PCT Int. Appl. (May 2007), 60/939, 586

4. Pyridazine-based SCD-1 inhibitors for use in combination therapy to treat adverse weight gain associated with a drug therapy Abreo, Melwyn; Kondratenko, Mikhail; Harvey, Daniel; Hudson, Cindy; Li, Wenbao; Tu, Chi; Sun, Sengen; Holladay, Mark; Gschwend, Heinz; Kamboj, Rajender; Winther, Michael; Fraser, Robert; Sadalapure, Kashinath; Chafeev, Mikhail; Fu, Jian-Min; Hou, Duanjie; Liu, Shifeng; Raina, Vandna; Seid Bagherzadeh, Mehran. (Xenon Pharmaceuticals Inc., Canada). PCT Int. Appl. (2006)149 pp. WO 2006086445 A2 20060817 Application: WO 2006-US4383 20060208. Priority: US 2005-651584 20050209.

5. Preparation of piperazinylimidazo[1,2-b]pyridazine-2-carboxamides as inhibitors of Stearoyl-CoA Desaturase, Kamboj, Rajender; Fu, Jian-Min; Kodumuru, Vishnumurthy; Liu, Shifeng; Sadalapure, Kashinath; Chakka, Nagasree; Hou, Duanjie; Sun, Shaoyi. (Xenon Pharmaceuticals Inc., Canada). PCT Int. Appl. (2006), 72 pp. WO 2006034312 A1 20060330. Application: WO 2005-US33738, 20050920. Priority: US 2004-611646, 20040920.

6. Preparation of pyridazinylpiperazinyl trifluorophenyl methanones as stearoyl-CoA desaturase inhibitors, Kamboj, Rajender; Zhang, Zaihui; Fu, Jian-Min; Kodumuru, Vishnumurthy; Sviridov, Serguei; Sadalapure, Kashinath; Liu, Shifeng; Sun, Shaoyi; Hou, Duanjie; Chakka, Nagasree, (Xenon Pharmaceuticals Inc., Can.). PCT Int. Appl. (2006), 77 pp. WO 2006034440, A2 20060330. Application: WO 2005-US34129 20050920. Priority: US 2004-611644, 20040920.

7. Preparation of salacinol sulfate-containing alditols as glycosidase inhibitors and antidiabetic agents, Pinto, Brian Mario; Johnston, Blair D.; Ghavami, Ahmad; Szczepina, Monica Gabriela; Liu, Hui; Sadalapure, Kashinath; Jensen, Henrik H.; Kumar, Nag Sharwan; Nasi, Ravindranath, (Simon Fraser University, Canada). U.S. Pat. Appl. Publ. (2006), 121 pp., Application: US 2006-368014, 20060302.

8. Preparation of salacinol sulfate-containing alditols as glycosidase inhibitors and antidiabetic agents, Pinto, Brian Mario; Johnston, Blair D.; Szczepina, Monica Gabriela; Liu, Hui; Sadalapure, Kashinath; Ghavami, Ahmad. U.S. Pat. Appl. Publ. (2005), 62 pp., Cont.-in-part of U.S. Ser. No. 226,657.

9. Methods for synthesis of substituted tetrahydrofuran compounds Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah and others. International Patent # WO 00/01683 dated Jan. 13, 2000.

10. Substituted Oxygen Alicyclic Compounds, Including Methods for Synthesis thereof Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Vavilala Goverdhan Reddy, Bethi Sridhar Reddy, Hymavathi Lanka, Aminul Islam, Chittineni Hariprasad, Alla Venkata Rama Rao. International Patent # WO 00/01381 dated Jan. 13, 2000.

11. Substituted oxygen alicyclic compounds, including methods for synthesis thereof Adhikari S. S.; Krishna L. M.; Prasad T. R.; RAO A. V. R.; Rao B. V.; Reddy B. S.; Islam A.; Lanka H.; Sreenivas P.; Gurjar M. K.; Krishna P. R.; Murugaih A. M. S.; Prasad C. H.; Reddy V. G.; Sadalapure K.; Sharma G. V. M.; Lalitha S. V. S.; Chorghade M. S.; Mhaskar S. V. US Patent No. 6566538.

12. Methods of synthesis of substituted tetrahydrofuran compound Adhikari S. S.; Krishna L. M.; Prasad T. R.; RAO A. V. R.; Rao B. V.; Reddy B. S.; Islam A.; Lanka H.; Sreenivas P.; Gurjar M. K.; Reddy V. G.; Sadalapure K.; Sharma G. V. M.; Lalitha S. V. S.; Chorghade M. S.; Mhaskar S. V. US Patent No. 6541647.

13. Substituted oxygen alicyclic compounds, including methods for synthesis thereof Adhikari S. S.; Krishna L. M.; Prasad T. R.; RAO A. V. R.; Rao B. V.; Reddy B. S.; Islam A.; Lanka H.; Sreenivas P.; Gurjar M. K.; Krishna P. R.; Murugaih A. M. S.; Prasad C. H.; Reddy V. G.; Sadalapure K.; Sharma G. V. M.; Lalitha S. V. S.; Chorghade M. S.; Mhaskar S. V. US Patent No. 6433197.

14. Methods for synthesis of substituted tetrahydrofuran compound Adhikari S. S.; Krishna L. M.; Prasad T. R.; RAO A. V. R.; Rao B. V.; Reddy B. S.; Islam A.; Lanka H.; Sreenivas P.; Gurjar M. K.; Krishna P. R.; Murugaih A. M. S.; Prasad C. H.; Reddy V. G.; Sadalapure K.; Sharma G. V. M.; Lalitha S. V. S.; Chorghade M. S.; Mhaskar S. V. US Patent No. 6310221.

15. Substituted oxygen alicyclic compounds, including methods for synthesis thereof Adhikari S. S.; Krishna L. M.; Prasad T. R.; RAO A. V. R.; Rao B. V.; Reddy B. S.; Islam A.; Lanka H.; Sreenivas P.; Gurjar M. K.; Krishna P. R.; Murugaih A. M. S.; Prasad C. H.; Reddy V. G.; Sadalapure K.; Sharma G. V. M.; Lalitha S. V. S.; Chorghade M. S.; Mhaskar S. V. US Patent No. 6306895.

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